Written by: The Midland Certified Reagent Company

Oligonucleotides aid researchers in allocating certain issues within genetic diseases.

Advanced techniques have greatly simplified labeling oligonucleotides and their conjugates. Studies have shown that they are now less tedious, more cost-efficient, and more effective than ever before. These new techniques have given researchers the ability to utilize moieties such as a fluorescent label that’s consisted of a dye or biotin. There have been huge strides taken in the development of new, and improved, labeling methods that give a more “refined” role for oligonucleotides.

What is their use?

There are some key procedures that fluorescent-dye-labeled oligonucleotides take part in, including PCR, restriction mapping, genetic research, and DNA sequencing. They have also become one of the most reliable dye attachments when it comes to either DNA or RNA synthesis.

Importance

The dye labeling of synthetic oligonucleotides is extremely important in analytical biotechniques. The production of these synthetically-dyed oligonucleotides is done in a shorter time and in high yield with a high purity.

The importance of their design translates beyond the procedures as they have proved to assist in things that surpass simple research purposes. Genetic diseases are being evaluated with these oligonucleotides and researchers are uncovering more information and details about them than ever before. The details that come from this research also affect how various treatments can be developed to help minimize the effects and even prevent lives from being consumed by the genetic disease as well. Researchers are constantly battling to find an effective cure for these global diseases and by advancing small role players such as these oligonucleotides and uncovering more about their structures in both RNA and DNA synthesis, progress can be made little by little.